Yıl: 2005 Cilt: 2 Sayı: 1 Sayfa Aralığı: 11 - 15 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Antimicrobial activity of 4-subtituted-styrl-2-azetindinones

Öz:
Bu çalışmada, daha önceden sentezleri yapılan 1-(substitutefenil)-4-(substiiuestril)-2-azetidinonlarin (3a-i) antimikrobiyal aktiviteleri incelenmiştir. Bütün bileşikler Gram (+) ve Gram (-) bakterilere ve mayaya karşı test edilmiştir. Aktivite, halkadaki substituentlerden önemli derecede etkilenmediği bulundu
Anahtar Kelime: Yapı-aktivite ilişkisi Azetidinler Farmakoloji Mikrobiyal duyarlılık testleri Kimya

Konular: Farmakoloji ve Eczacılık

4-substitue-stiril-2-azetidinonların antimikrobiyal aktivitesi

Öz:
In this study, antimicrobial activity of previously synthesized 1 -(Substituted phenyl)-4-(substituted styryl)-2-azetidinones(3a-i) have been examined. All compounds have been tested against Gram(+) and Gram(-) bacteria and yeasts. It was found that activity is not significantly influenced by the substitiients on the ring
Anahtar Kelime: Structure-Activity Relationship Azetidines Pharmacology Microbial Sensitivity Tests Chemistry

Konular: Farmakoloji ve Eczacılık
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1.Brown, A.G., " Discovery and development of new (3-Lactam antibiotics" Pure and App, Chem., 59(3), 475-484,1987.
  • 2.Mukerjee A.K., Signh, A.K., "(3-Lactams: Retrospect and Prospect" Tetrahedron, 34, 1731-1767,1978.
  • 3.Morin, R. B. and Gorman, M., Chemistry and Biology of (3-Lactam Antibiotics, Academic Press, New York,, vols. 1-3, 1982.
  • 4.Banik, B.K., Becker, F.F. and Banik, I. "Synthesis of anticancer (3 -lactams: mechanism of action" Bioorganic & Medicinal Chemistry, 12 2523-2528, 2004.
  • 5.Kazi, A., Hill R., Long T.E., Kuhn D.J., Turos E., Dou Q.P. "Novel N-thiolated P -lactam antibiotics selectively induce apoptosis in human tumor and transformed, but not normal or nontransformed, cells" Biochemical Pharmacology, 67(2), 365-374, 2004.
  • 6.Veinberg, G., Vorona, M., Shestakova, L, Kanepe, I., Zharkova, O., Mezapuke, R., Turovskis, I., Kalvinsh, I., Lukevics, E. "Synthesis and antitumor activity of selected 7- alkylidene substituted cephems", Bioorg. Med. Chem. 8, 1033, 2000.
  • 7.Banik, I.; Becker, F. F.; Banik, B. K. "Stereoselective Synthesis of (3-Lactams with Polyaromatic Imines: Entry to New and Novel Anticancer Agents", J. Med. Chem., 46, 12- 15,2003.
  • 8.Guner, V., Yildirir, S., Ozcelik, B., Abbasoglu, U.," Synthesis and antimicrobial activity of l,4-diaryl-2-azetidinones"//Farmaco, 55, 147-150,2001.
  • 9.Kumar, R., Giri, S., Nizamuddin, B., " Synthesis and fungicidal activity of 1-(substituted phenyl)-3-substituted-4-styryl-2-azetidinones as Potential" J. Pesticide Sci., 9-13,1993.
  • 10.Duirno, M.V., Mazzoni, O., Piscopa, E., Bolognose, A., " Synthesis and antimicrobial activity of l,3,4-triaryl-2-azetidinones", II Farmaco, 47(2), 239-247,1992.
  • 11.Walsh, O., Meegan, M.J., Prendergast, R.M., Nakib, T.A.," Synthesis of 3-acetoxyazetidin- 2-ones and 3-hydroxyazetidi-2-ones with antifungal and antibacterial activity" Eur. J. Med. Chem. 31,989-1000, 1996.
  • 12.Kabak, M., Elerman, Y., Güner, V., and Durlu, T.N., " N-(p-chlorophenyl)-3,3-diphenyl- 4-(p-phenylstyryl)azetidin-2-one" Açta Cryst. C56, e207-208, 2000.
  • 13.Kabak, M., Güner, V., Elerman, Y., and Durlu, T.N., " Crystal structure of 3,3-dichloro- N-p-methoxyphenyl-4-2-(phenylstyryl)-2-azetidinon" Analytical Sciences, 17(7), 909-910,2001.
  • 14.Guner, V. "Heterocycles by Ketene Cycloaddition with Heterodienes. Parti: (3- Lactams and h-Lactams", Turkish J. Chem., 2005 in press.
  • 15.D.F. Sahm, J.A. Washington, in: A. Balows, W.J. Hawler, (eds.), Manual of ClinicalMicrobiology, American Society for Microbiology, Washington DC, pp. 1105, 1991.
  • 16.C. Thornsberry, T.L. Gavon, E.H. Gerlach, G. Cumitech, Am. Soc. Microbiol., 1, 1-14,1973.
APA TAN S, GÜNER A, Ergene A (2005). Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. , 11 - 15.
Chicago TAN Sema,GÜNER Adar Vildan,Ergene Aysun Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. (2005): 11 - 15.
MLA TAN Sema,GÜNER Adar Vildan,Ergene Aysun Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. , 2005, ss.11 - 15.
AMA TAN S,GÜNER A,Ergene A Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. . 2005; 11 - 15.
Vancouver TAN S,GÜNER A,Ergene A Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. . 2005; 11 - 15.
IEEE TAN S,GÜNER A,Ergene A "Antimicrobial activity of 4-subtituted-styrl-2-azetindinones." , ss.11 - 15, 2005.
ISNAD TAN, Sema vd. "Antimicrobial activity of 4-subtituted-styrl-2-azetindinones". (2005), 11-15.
APA TAN S, GÜNER A, Ergene A (2005). Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. Turkish Journal of Pharmaceutical Sciences, 2(1), 11 - 15.
Chicago TAN Sema,GÜNER Adar Vildan,Ergene Aysun Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. Turkish Journal of Pharmaceutical Sciences 2, no.1 (2005): 11 - 15.
MLA TAN Sema,GÜNER Adar Vildan,Ergene Aysun Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. Turkish Journal of Pharmaceutical Sciences, vol.2, no.1, 2005, ss.11 - 15.
AMA TAN S,GÜNER A,Ergene A Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. Turkish Journal of Pharmaceutical Sciences. 2005; 2(1): 11 - 15.
Vancouver TAN S,GÜNER A,Ergene A Antimicrobial activity of 4-subtituted-styrl-2-azetindinones. Turkish Journal of Pharmaceutical Sciences. 2005; 2(1): 11 - 15.
IEEE TAN S,GÜNER A,Ergene A "Antimicrobial activity of 4-subtituted-styrl-2-azetindinones." Turkish Journal of Pharmaceutical Sciences, 2, ss.11 - 15, 2005.
ISNAD TAN, Sema vd. "Antimicrobial activity of 4-subtituted-styrl-2-azetindinones". Turkish Journal of Pharmaceutical Sciences 2/1 (2005), 11-15.