The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose

GÜVEN, Aysel; YILMAZ, Seval

The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose

Aysel GÜVEN, (Kafkas Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Biyokimya Anabilim Dalı, Kars, Türkiye)

Seval YILMAZ (Kafkas Üniversitesi, Fen Edebiyat Fakültesi, Biyoloji Bölümü, Biyokimya Anabilim Dalı, Kars, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

2 0

Yıl: 2005 Cilt: 11 Sayı: 2 Sayfa Aralığı: 113 - 117 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose

Öz:

Plazma ve dokularda lipid peroksid düzeyleri çeşitli organ ve hücrelerdeki bozunmaya bağlı hastalıklar ile pozitif bir korelasyon gösterir. Çalışmada Kaz karaciğeri ve böbreklerinde karbon tetraklorür ve etil alkol ile oluşturulan doku hasarlarında lipid peroksidasyonunun bir ürünü olan malondialdehit ve antioksidan defans sistemi araştırıldı. Çalışmada 40 adet 200-250 g klinik olarak sağlıklı 3 haftalık Anser anser ırkı kaz palazı kullanıldı. Hayvanlar 4 eşit Gruba ayrıldı. Birinci grup kontrol grubunu oluşturmuştur. Bu Grup standart yem ve su ile ad libutum olarak beslendi. İkinci Gruba canlı ağırlık başına 1 ml/kg CC14, III. Gruba 1.5 ml/kg CC14 ve IV. gruba da %50'lik etil alkolden kilogram başına 5 ml/kg haftada üç kez olmak üzere 12 hafta boyunca oral yolla verildi. Bu çalışma sonunda karaciğer ve böbreklerde hasara bağlı olarak malondialdehide (MDA) düzeylerinde artış, glutatyon peroksidaz" (GSH-Px), katalaz (CAT), glukoz-6fosfat dehidrogenaz (G6PD) aktivitelerinde azalma görüldü.

Anahtar Kelime: karbon tetraklorür toksik maddeler karaciğer böbrekler kümes hayvanları kaz glukoz-6-fosfat dehidrogenaz etanol toksisite lipit peroksidasyonu glutatyon peroksidaz katalaz

Konular: Biyokimya ve Moleküler Biyoloji

Karbon tetraklorür $(CCl_4)$ ve etil alkol $(C_2H_5OH)$ ün kaz karaciğer ve böbreklerinde glutatyon peroksidaz, katalaz, glukoz-6-fosfat dehidrogenaz enzim aktiviteleri ve lipid peroksidaz düzeylerine etkilerinin belirlenmesi

Öz:

The elevation of plasma and tissue lipid peroxide levels is an indicator of membrane disruption in various tissue and organ cells and it is positively correlated with the gravity of the disease. Changes in the liver of malondialdehyde (MDA, a degreedative product of lipid peroxidation) and in the antioxidant defence system in geese with alcohol and carbon tetrachloride-induced liver and kidney degeneration were studied. The experiments were carried out on 3 week-old clinically healthy (40 animals), geese (Anser anser) weighing 200-250 g divided into control and experimental groups of 10 animals each. The first group was used as the control group. The second group was given 1 ml/kg b.w. CC14 while the third group was given 1.5 ml/kg b.w. CC14. The fourth group was given 50 % ethanol (5 ml/kg b.w). The treatment was made tree times a week for 12 weeks. 1 and 1.5 (ml/kg b.w) doses of CC14 and ethanol increased the malondialdehyde level of the liver as a consequence of the lipid peroxidation. At the results of this study malondialdehide (MDA) levels was increase and glutathione peroxidase (GSH-Px), catalase (CAT), glucose-6 phosphate dehidrogenase (G6PD) were decrease as according to the liver and kidney tissue's degeneration

Anahtar Kelime: glucose-6-phosphate dehydrogenase ethanol toxicity lipid peroxidation glutathione peroxidase catalase carbon tetrachloride toxic substances liver kidneys poultry geese

Konular: Biyokimya ve Moleküler Biyoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜVEN A, YILMAZ S (2005). The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. , 113 - 117.
Chicago	GÜVEN Aysel,YILMAZ Seval The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. (2005): 113 - 117.
MLA	GÜVEN Aysel,YILMAZ Seval The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. , 2005, ss.113 - 117.
AMA	GÜVEN A,YILMAZ S The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. . 2005; 113 - 117.
Vancouver	GÜVEN A,YILMAZ S The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. . 2005; 113 - 117.
IEEE	GÜVEN A,YILMAZ S "The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose." , ss.113 - 117, 2005.
ISNAD	GÜVEN, Aysel - YILMAZ, Seval. "The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose". (2005), 113-117.

APA	GÜVEN A, YILMAZ S (2005). The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 11(2), 113 - 117.
Chicago	GÜVEN Aysel,YILMAZ Seval The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 11, no.2 (2005): 113 - 117.
MLA	GÜVEN Aysel,YILMAZ Seval The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.11, no.2, 2005, ss.113 - 117.
AMA	GÜVEN A,YILMAZ S The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2005; 11(2): 113 - 117.
Vancouver	GÜVEN A,YILMAZ S The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2005; 11(2): 113 - 117.
IEEE	GÜVEN A,YILMAZ S "The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 11, ss.113 - 117, 2005.
ISNAD	GÜVEN, Aysel - YILMAZ, Seval. "The effect of carbon tetrachloride $(CCl_4)$ AND ETHANOL $(C_2H_5OH)$ on the determination of levels glutathione peroxidase, catalase, glucose-6-phosphate dehidrogenase and lipid peroxidation liver and kidney in the goose". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 11/2 (2005), 113-117.