Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

FİDAN, A.Fatih; ERYAVUZ, ABDULLAH; AVCI, Gülcan; BÜLBÜL, Aziz; KÜÇÜKKURT, İsmail; ÖZTAŞAN, Nuray

Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

Nuray ÖZTAŞAN, (Afyon Kocatepe Üniversitesi, Tıp Fakültesi, Psikoloji Bölümü, Afyon, Türkiye)

Aziz BÜLBÜL, (Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Afyon, Türkiye)

Abdullah ERYAVUZ, (Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Afyon, Türkiye)

Gülcan AVCI, (Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Afyon, Türkiye)

İsmail KÜÇÜKKURT, (Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Afyon, Türkiye)

A.Fatih FİDAN (Afyon Kocatepe Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Afyon, Türkiye)

Ankara Üniversitesi Veteriner Fakültesi Dergisi

1 0

Yıl: 2008 Cilt: 55 Sayı: 3 Sayfa Aralığı: 149 - 153 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats

Öz:

Bu çalışmada, L-NAME ile hipertansiyon oluşturulmuş sıçanlarda diyete Yucca schidigera ekstraktı (YSE) ilavesinin kan basıncı, antioksidan aktivite (AA) ve bazı biyokimyasal parametreler üzerine etkileri araştırıldı. Araştırmada, 18 adet erkek Sprague-Dawley sıçan kullanıldı ve sıçanlar; 1) standart diyetle adlibutum beslenen kontrol grubu, 2) içme sularına günde 75 mg/L N-nitro-L-arginine methyl ester (L-NAME) uygulanan grup ve 3) içme sularında L-NAME alan grubun diyetine 125 ppm YSE uygulanan grup olmak üzere her biri 6 sıçandan oluşan üç gruba ayrıldı. Araştırma 4 hafta sonra sonlandırıldı. L-NAME uygulanan sıçanlarda ortalama arteriyel kan basıncı (OAKB) kontrol ve YSE+L-NAME gruplarına göre yüksek çıktı. Kalp atım sayısı ise YSE+L-NAME uygulanan sıçanlarda kontrol ve L-NAME grubuna göre düşük belirlendi. L-NAME uygulaması NO metabolitleri (NOx) ile vitamin A düzeyini azaltırken, β-karoten ve methemoglobin değerlerini artırdı. Sonuç olarak, L-NAME ile hipertansiyon oluşturulmuş sıçanların diyetine YSE ilavesinin NO oluşumunu artırarak ortalama arteriyel kan basıncını düzenleyebileceği düşünülmektedir.

Anahtar Kelime: geleneksel ilaçlar bitki özütü Yucca schidigera A vitamini retinol farmakoloji kan basıncı sıçan kolesterol odun olmayan orman ürünleri antioksidanlar

Konular: Veterinerlik

L-NAME ile hipertansiyon oluşturulmuş sıçanlarda diyete Yucca schidigera ekstraktı (YSE) ilavesinin kan basıncı, antioksidan aktivite ve bazı biyokimyasal parametreler üzerine etkisi

Öz:

The present study was aimed at investigating the effects of dietary supplementation of Yucca schidigera extract (YSE) on blood pressure, antioxidant activity and some biochemical parameters in the L-NAME-induced hypertensive rats. The study was performed on eighteen male Sprague-Dawley rats divided into 3 groups with 6 animals per group: 1) Control, fed standard chow ad libitum, 2) N-nitro-L-arginine methyl ester (L-NAME)-treated group, 75 mg/L drinking water, 3) YSE+L-NAME group, YSE (125 mg/kg diet)+L-NAME (75 mg/L drinking water), through study period lasted at 4 weeks. L-NAME-treated rats had significantly (P<0.05) higher the mean arterial blood pressure (MABP) as compared with the rats in the control and YSE+L-NAME groups. L-NAME+YSE-treated rats had lower heart rate (HR) as compared to the L-NAME-treated and control rats and, higher MABP as compared to the control rats. Plasma concentration of NO metabolites (NOx) decreased after treatment with L-NAME. LNAME+ YSE-treatment increased the plasma malondialdehyde (MDA) and NOx concentration but decreased the antioxidant activity (AA), glucose, total cholesterol and total protein levels as compared to the other groups. The L-NAME-treatment decreased the vitamin A, but increased the beta-carotene and methemoglobin concentrations as compared to the other groups. In conclusion, these results may suggest that YSE ameliorates the increase of MABP in the L-NAME-induced hypertension by enhanced generation of vascular NO.

Anahtar Kelime: vitamin A retinol pharmacology blood pressure rats cholesterol non-wood forest products antioxidants traditional medicines plant extracts Yucca schidigera

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Achan V, Tran CT, Arrigoni F, Whitley GS, Leiper JM, Vallance P (2002): All- trans retinoic acid increases nitric oxide synthesis by endothelial cells: a role for the induction of dimethylearginine dimethlylaminohydrolase. Circ Res, 90, 764-769.
2. Achike FI, Kwan CY (2003): Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway. Clin Exp Pharmacol Physiol, 30, 605-615.
3. Akpolat AZ, Borlu F, Dogan S, Onrat E, Kaya D, Esen A M (2002): Oksidan, antioksidan mekanizmalar ve hipertansiyon. Hipokrat Kard Derg, 23, 108-112.
4. Aslan R, Dündar Y, Eryavuz A, Bülbül A, Fidan F, Küçükkurt İ (2005): Effects of various quantities of Yucca shidigera powder (Deodorase) added to diets on performance, some hemotological and biochemical blood parameters and total antioxidant capacity of laying hens. Revue Med Vet, 156, 350-355.
5. Blomhoff R, Gren MH, Berg T, Norum KR (1990): Transport and storage of vitamin A. Science, 250, 399-404.
6. Cheeke PP (1998): Saponins: surprising benefits of desert plants,4-5. In: The Linus Pauling Institute Newsletter, OR Corvallis (Ed), Oregon State University Press, Oregon.
7. Chen PY, Gladish RD, Sanders PW (1998): Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats. Hypertension, 31, 918–924.
8. Cracowski JL, Baguet JP, Ormezzano O, Bessard J, Stanke-Labesque F, Bessard G, Mallion JM (2003): Lipid peroxidation is not increased in patients with untreated mild-to-moderate hypertension. Hypertension, 41, 286-288.
9. Dongmo AB, Kamanyi A, Franck U, Wagner H (2002): Vasodilating properties of extracts from the leaves of Musanga cecropioides (R Brown). Phytother Res, 16, 6-9.
10. Draper HH, Hardley M (1990): Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol, 186, 421-431.
11. Eryavuz A, Dundar Y, Aslan R, Cengiz N (2001): Investigation of the blood glutathione and malondialdehyde levels in tannery workers. Kocatepe Tıp Derg, 2, 147-151.
12. Fairbanks VF, Klee GG (1987): Biochemical aspect of haematology, 803-804. In: Fundamentals of Clinical Chemistry, NW Tietz (Ed), Saunders, Philadelphia.
13. Francis G, Kerem, Makkar HPS, Becker K (2002): The biological action of saponins in animal systems: a review. Br J Nutr, 88, 587-605.
14. Gaziano JM, Hennekens CH (1993): The role of betacarotene in the prevention of cardiovascular disease, 148- 155 In: Carotenoids in Human Health, LM Canfield (Ed), New York Academy of Sciences, New York.
15. Jenkins KJ, Atwal AS (1994): Effects of dietary saponins on fecal bile acids and neutral sterols, and availability of vitamins A and E in the chick. J Nutr Biochem, 5, 134-138.
16. Jeon B H, Kim CS, Kim HS, Park JB, Nam KY, Chang SJ (2000): Effect of korean red ginseng on blood pressure and nitric oxide production. Acta Pharmacol, 21, 1095-1100.
17. Jeon BH, Kim CS, Park KS, Lee JW, Park JB, Kim KJ, Kim SH, Chang SJ, Nam KY (2000) : Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats. Gen Pharmacol, 35, 135-141.
18. Kang DG, Sohn EJ, Lee YM, Lee AS, Han JH, Kim TY, Lee HS (2004): Effects of bulbus Fritillaria water extract on blood pressure and renal functions in the LNAME induced hypertensive rats. J Ethnopharm, 91, 51-56.
19. Katz D, Mazor D, Dvilansky A, Meyerstein N (1996): Effect of radiation on red cell membrane and ıntra cellular oxidative defense system. Free Radical Res, 24, 199-204.
20. Kim SW, Park SK, Kang SI, Kang HC, Oh HJ, Bae CY, Bae DH (2003): Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body. Arch Pharm Res, 26, 1042-1046.
21. Koracevic D, Koracevic G, Djordjevic V, Andrejevic S, Cosic V (2001): Method for the measurement of antioxidant activity in human fluids. J Clin Pathol, 54, 356-361.
22. Kudo K, Tachikawa E, Kashimoto T, Takahashi E (1998): Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells. Eur J Pharmacol, 341, 139-144.
23. Lansink M, Bennekum AM, Blaner WS, Kooistr T (1999): Differences in metabolism and isomerization of all-trans-retinoic acid and 9-cis-retinoic acid between human endothelial cells and hepatocytes. Eur J Biochem, 247, 596–604.
24. Miranda KM, Espey MG, Wink DAA (2001): Rapid, simple spectrophotometric method for detection of nitrate and nitrite. Nitric Oxide, 5, 62-71
25. Nishiyama A, Fujisawa Y, Fukui T, Rahman M, Kondo N, Ogawa Y, Fanzhu L, Guoxing Z, Kimura S, Abe Y (2001): Role of nitric oxide in regional blood flow in angiotensin II-induced hypertensive rats. Hypertens Res, 24, 421-427.
26. Oleszek W, Sitek M, Stochmal A, Piacente S, Pizza C, Cheeke P (2001): Steroidal saponins of Yucca schidigera roezl. J Agr Food Chem, 49, 4392–4397.
27. Piacente S, Montoro P, Oleszek W, Pizza C (2004): Yucca schidigera bark: phenolic constituents and antioxidant activity. J Nat Prod, 67, 882-885.
28. Price KR, Johnson IT, Fenwick GR (1987): The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr, 26, 127-135.
29. Rhiouani H, Settaf A, Lyoussi B, Cherrah Y, Lacaille-Dubois MA, Hassar M (1999): Effects of saponins from Herniaria glabra on blood pressure and renal function in spontaneously hypertensive rats. Therapie, 54, 735-739.
30. Shaish A, Daugherty A, O'Sullivan F, Schonfeld G, Heinecke JW (1995): Beta carotene inhibits atherosclerosis in hypercholesterolemic rabbits. J Clin Invest, 96, 2075–2082.
31. Sidhu GS, Oakenfull DG (1986): A mechanism for the hypocholesterolaemic activity of saponins. Br J Nutr, 55,643-649.
32. Suzuki J, Katoh NA (1990): Simple and cheap methods for measuring serum vitamin-A in cattle using only a spectrophotometer. Nippon Juigaku Zasshi, 52, 1281-1283.
33. Vallance P, Leone A, Calver A, Collier J, Moncada S (1992) : Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet, 339, 572–575.
34. Welch WJ, Tojo A, Wilcox CS (2000): Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol, 278, 69-776.
35. Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, Hassar M (2000): Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie, 55, 379-382.
36. Zinchuk VV, Pronko TP, Lis MA (2004): Blood oxygen transport and endothelial dysfunction in patients with arterial hypertension. Clin Physiol Funct Imaging, 24, 205-211.

APA	ÖZTAŞAN N, BÜLBÜL A, ERYAVUZ A, AVCI G, KÜÇÜKKURT İ, FİDAN A (2008). Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. , 149 - 153.
Chicago	ÖZTAŞAN Nuray,BÜLBÜL Aziz,ERYAVUZ ABDULLAH,AVCI Gülcan,KÜÇÜKKURT İsmail,FİDAN A.Fatih Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. (2008): 149 - 153.
MLA	ÖZTAŞAN Nuray,BÜLBÜL Aziz,ERYAVUZ ABDULLAH,AVCI Gülcan,KÜÇÜKKURT İsmail,FİDAN A.Fatih Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. , 2008, ss.149 - 153.
AMA	ÖZTAŞAN N,BÜLBÜL A,ERYAVUZ A,AVCI G,KÜÇÜKKURT İ,FİDAN A Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. . 2008; 149 - 153.
Vancouver	ÖZTAŞAN N,BÜLBÜL A,ERYAVUZ A,AVCI G,KÜÇÜKKURT İ,FİDAN A Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. . 2008; 149 - 153.
IEEE	ÖZTAŞAN N,BÜLBÜL A,ERYAVUZ A,AVCI G,KÜÇÜKKURT İ,FİDAN A "Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats." , ss.149 - 153, 2008.
ISNAD	ÖZTAŞAN, Nuray vd. "Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats". (2008), 149-153.

APA	ÖZTAŞAN N, BÜLBÜL A, ERYAVUZ A, AVCI G, KÜÇÜKKURT İ, FİDAN A (2008). Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 55(3), 149 - 153.
Chicago	ÖZTAŞAN Nuray,BÜLBÜL Aziz,ERYAVUZ ABDULLAH,AVCI Gülcan,KÜÇÜKKURT İsmail,FİDAN A.Fatih Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi 55, no.3 (2008): 149 - 153.
MLA	ÖZTAŞAN Nuray,BÜLBÜL Aziz,ERYAVUZ ABDULLAH,AVCI Gülcan,KÜÇÜKKURT İsmail,FİDAN A.Fatih Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol.55, no.3, 2008, ss.149 - 153.
AMA	ÖZTAŞAN N,BÜLBÜL A,ERYAVUZ A,AVCI G,KÜÇÜKKURT İ,FİDAN A Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2008; 55(3): 149 - 153.
Vancouver	ÖZTAŞAN N,BÜLBÜL A,ERYAVUZ A,AVCI G,KÜÇÜKKURT İ,FİDAN A Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2008; 55(3): 149 - 153.
IEEE	ÖZTAŞAN N,BÜLBÜL A,ERYAVUZ A,AVCI G,KÜÇÜKKURT İ,FİDAN A "Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats." Ankara Üniversitesi Veteriner Fakültesi Dergisi, 55, ss.149 - 153, 2008.
ISNAD	ÖZTAŞAN, Nuray vd. "Effect of Yucca schidigera extract on blood pressure, antioxidant activity and some blood parameters in the L-name-induced hypertensive rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 55/3 (2008), 149-153.