İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi
Proje Grubu: TBAG Sayfa Sayısı: 36 Proje No: 112T714 Proje Bitiş Tarihi: 01.02.2014 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi
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Anahtar Kelime: Erişim Türü: Erişime Açık
- Azoitei, N. et al. Glioblastoma growth and tumor formation. Neuro. Oncol. 13, 710–724 (2011).
- Bangert A, Cristofanon S, Eckhardt I, Abhari B A, Kolodziej S, Häcker S, Vellanki S H K,Lausen J, Debatin K M and Fulda S. Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP. Oncogene 31, 4677-4688. (2012)
- Basu, A., PKC and resistance to chemotherapeutic agents, Protein kinase C in cancer signaling and therapy, ed: Kazanietz, M.G., Springer Science + Business Media, New York, 2010, pg.409-411
- Becker W. M., Kleinsmith L. J., Hardin J. The world of the cell, Pearson Education, San Francisco, (2006), pg. 762-775
- Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248–54 (1976).
- Chen, J. et al. PKD2 mediates multi-drug resistance in breast cancer cells through modulation of P-glycoprotein expression. Cancer Lett. 300, 48–56 (2011).
- Davis, J. M. et al. Raf-1 and Bcl-2 Induce Distinct and Common Pathways That Contribute to Breast Cancer Drug Resistance Raf-1 and Bcl-2 Induce Distinct and Common Pathways That Contribute to Breast Cancer Drug Resistance 1. 1161–1170 (2003).
- Day, T. W. et al. c-FLIP gene silencing eliminates tumor cells in breast cancer xenografts without affecting stromal cells. Anticancer Res. 29, 3883–6 (2009).
- Doyle, L. A. & Ross, D. D. Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2). Oncogene 22, 7340–58 (2003).
- Eiseler, T., Döppler, H., Yan, I. K., Goodison, S. & Storz, P. Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res. 11, R13 (2009).
- Gill, P. K., Gescher, a & Gant, T. W. Regulation of MDR1 promoter activity in human breast carcinoma cells by protein kinase C isozymes alpha and theta. Eur. J. Biochem. 268, 4151–7 (2001).
- Gomez-Lazaro, M. et al. 6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA. J. Neurochem. 104, 1599–612 (2008).
- Gottesman, M. M., Fojo, T. & Bates, S. E. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48–58 (2002).
- Hao, Q., McKenzie, R., Gan, H. & Tang, H. Protein kinases D2 and D3 are novel growth regulators in HCC1806 triple-negative breast cancer cells. Anticancer Res. 33, 393–9 (2013).
- Hao, Q., Wang, L., Zhao, Z. J. & Tang, H. Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis. J. Biol. Chem. 284, 799–806 (2009).
- Işeri, O. D. et al. Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern. Biomed. Pharmacother. 65, 40–5 (2011).
- Kaplan, E. & Gündüz, U. Expression analysis of TOP2A, MSH2 and MLH1 genes in MCF7 cells at different levels of etoposite resistance. Biomed. Pharmacother. 66, 29–35 (2012).
- Karam, M., Legay, C., Auclair, C. & Ricort, J.-M. Protein kinase D1 stimulates proliferation and enhances tumorigenesis of MCF7 human breast cancer cells through a MEK/ERK-dependent signaling pathway. Exp. Cell Res. 318, 558–69 (2012).
- Kars, M. D. et al. Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds. Anticancer Res. 26, 4559–68 (2006).
- Kars, M. D., Işeri, O. D., Ural, A. U. & Gündüz, U. In vitro evaluation of zoledronic acid resistance developed in MCF7 cells. Anticancer Res. 27, 4031–7 (2007).
- Liu, F., Xie, Z.-H., Cai, G.-P. & Jiang, Y.-Y. The effect of survivin on multidrug resistance mediated by P-glycoprotein in MCF7 and its adriamycin resistant cells. Biol. Pharm. Bull. 30, 2279–83 (2007).
- Longley, D. B. & Johnston, P. G. Molecular mechanisms of drug resistance. J. Pathol. 205, 275–92 (2005).
- Lu, X., Tied up in loops: positive and negative autoregulation of p53, The p53 family, ed: Levine, A. J., Lane, D.P., Cold Spring Harbor Laboratory Press, New York, 2010, pg. 117
- Nakano, K. & Vousden, K. H. PUMA , a Novel Proapoptotic Gene , Is Induced by p53 National Cancer Institute at Frederick. 7, 683–694 (2001).
- Rozengurt, E. Protein kinase D signaling: multiple biological functions in health and disease. Physiology (Bethesda). 26, 23–33 (2011).
- Rozengurt, E., Rey, O. & Waldron, R. T. Protein kinase D signaling. J. Biol. Chem. 280, 13205–8 (2005).
- Rozengurt, E., Regulation and function of protein kinase D signaling, Protein kinase C in cancer signaling and therapy, ed: Kazanietz, M.G., Springer Science + Business Media, New York, 2010, pg.138-139
- Scotto, K. W. Transcriptional regulation of ABC drug transporters. Oncogene 22, 7496–511 (2003).
- Steinberg, S. F. Regulation of protein kinase D1 activity. Mol. Pharmacol. 81, 284–91 (2012).
- Storz, P., Protein kinase D signaling in cancer, Cell Signaling & Molecular Targets in Cancer, ed: Chatterjee, M., Kashfi, K., NY: Springer New York, New York, 245-271, (2012)
- Trauzold, A. et al. PKCmu prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells. Oncogene 22, 8939–47 (2003).
- Urfali, Ç., Reversal of breast cancer resistance protein mediated multidrug resistance in MCF7 breast adenocarcionama cell line (M.Sc. thesis), Orta Doğu Teknik Üniversitesi, Fen Bilimleri Enstitüsü, (2012)
- Wang, L. et al. iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF7 cells and mouse thymocytes. Biochem. Biophys. Res. Commun. (2012). doi:10.1016/j.bbrc.2012.06.124
- Wang, Q. et al. Survivin up-regulates the expression of breast cancer resistance protein (BCRP) through attenuating the suppression of p53 on NF-κB expression in MCF7/5-FU cells. Int. J. Biochem. Cell Biol. 45, 2036–44 (2013).
- Wang, Z., Goulet, R., Stanton, K. J., Sadaria, M. & Nakshatri, H. Differential effect of anti-apoptotic genes Bcl-xL and c-FLIP on sensitivity of MCF7 breast cancer cells to paclitaxel and docetaxel. Anticancer Res. 25, 2367–79 (2005).
- Weinstein-oppenheimer, C. R. et al. Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin Role of the Raf Signal Transduction Cascade in the in Vitro Resistance to the Anticancer Drug Doxorubicin 1. 2898–2907 (2001).
- Yuan, J. et al. Protein kinase d regulates cell death pathways in experimental pancreatitis. Front. Physiol. 3, 60 (2012).
- Yuan, J. et al. Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother. Pharmacol. 63, 1103–10 (2009).
- Zhang, W. et al. Chemoresistance to 5-fluorouracil induces epithelial-mesenchymal transition via up-regulation of Snail in MCF7 human breast cancer cells. Biochem. Biophys. Res. Commun. 417, 679– 85 (2012).
- Zhou, J. et al. Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase. Cancer Res. 66, 445–52 (2006).
| APA | GÜNDÜZ U, AZARKAN S (2014). İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. , 1 - 36. |
| Chicago | GÜNDÜZ Ufuk,AZARKAN Serap Yalçın İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. (2014): 1 - 36. |
| MLA | GÜNDÜZ Ufuk,AZARKAN Serap Yalçın İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. , 2014, ss.1 - 36. |
| AMA | GÜNDÜZ U,AZARKAN S İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. . 2014; 1 - 36. |
| Vancouver | GÜNDÜZ U,AZARKAN S İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. . 2014; 1 - 36. |
| IEEE | GÜNDÜZ U,AZARKAN S "İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi." , ss.1 - 36, 2014. |
| ISNAD | GÜNDÜZ, Ufuk - AZARKAN, Serap Yalçın. "İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi". (2014), 1-36. |
| APA | GÜNDÜZ U, AZARKAN S (2014). İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. , 1 - 36. |
| Chicago | GÜNDÜZ Ufuk,AZARKAN Serap Yalçın İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. (2014): 1 - 36. |
| MLA | GÜNDÜZ Ufuk,AZARKAN Serap Yalçın İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. , 2014, ss.1 - 36. |
| AMA | GÜNDÜZ U,AZARKAN S İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. . 2014; 1 - 36. |
| Vancouver | GÜNDÜZ U,AZARKAN S İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi. . 2014; 1 - 36. |
| IEEE | GÜNDÜZ U,AZARKAN S "İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi." , ss.1 - 36, 2014. |
| ISNAD | GÜNDÜZ, Ufuk - AZARKAN, Serap Yalçın. "İlaç dirençli meme kanseri hücre hatlarında protein kinaz D2 ifadesinin dirençliliğe etki mekanizmalarının incelenmesi". (2014), 1-36. |
