Immune system vulnerability seems to play a significant role in the development and malignant transformation of pre-malignant squamous cell lesions.Emberger syndrome is a condition that affects the immune system, which is caused by GATA2 gene mutations. Our objective was to present the gynecologicexpressions of this rare syndrome in our case. Here, we discussed a relatively young patient with findings related to Emberger syndrome such as recurrentinfections, myelodysplastic syndrome, lower extremity edema, and multifocal, multicentric premalignant/malignant genital lesions. Sequencing of theGATA2 gene was accomplished for suspected Emberger syndrome and a point mutation in intron5, c1143+8C >T was detected. Gynecologists may play animportant role in the early detection of Emberger syndrome and guiding multidisciplinary treatment options as the initial signs related to this rare entitycan appear on the genitalia.
