Patients with sickle cell disease (SCD) tend to develop many renal abnormalities, including concentration defect, renal
papillary necrosis, and glomerulopathy that often presents with proteinuria. We report a case of a patient who presented
with sickle cell crisis and proteinuria. A diagnosis of SCD glomerulopathy was confirmed with renal biopsy. Treatment with
angiotensin-converting enzyme inhibitor was initiated, and proteinuria rapidly reduced to 0.27 g/day. It is crucial for a
clinician to recognize this important complication and take necessary precautions to delay progression to end-stage renal
disease.
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