• ÖZ

Isatis L. genus highly endemic and that is traditionally suggested for wound management in Turkey. In this study, we have reported the effect of I. glauca subsp. sivasica extract on diabetic wound healing process. A diabetic model was generated in Wistar rats using streptozotocin injection. Rats were divided into two main groups: control group and Isatis group. Full thickness excisional skin wounds were created by using a biopsy punch. The Isatis group was treated with single daily dose I. glauca subsp. sivasica extract (50 mg/kg). Rats were sacrificed day 3 or 7 after wounding. The dominant phenolic compounds identified with RP-HPLC-DAD from Isatis extract were the benzoic acid and vanillic acid. Isatis extract significantly accelerated wound healing process considering the wound closure rates (WCR). Moreover, the levels of collagen and nitric oxide were elevated on days 3 and 7 by Isatis administration in the diabetic wound tissue. These data suggest that, for the first time, I. glauca subsp. sivasica extract may have the potential to promote the impaired wound healing in patients with diabetes.

• ÖZ

VEGF has the positive effect on wound healing. In this study, the effect of VEGF application on some serum parameters during wound healing process were investigated. 36female normoglycemic Wistar rats were used (200–250 g). Dorsolateral incisional wounds(length: 4 cm) were made on the two sides of the medulla spinalis in rats. They were divided into 3 groups: untreated group (n=12), chitosan group (n=12) and chitosan+VEGFgroup (n=12). The rats were sacrificed on the 3rd and 7th days of post wounding. NOx,TBARs and RSH levels were determined spectrophotometrically in serum. Results werecompared by one-way ANOVA (p<0.05). Serum TBARs levels both the chitosan treatedgroup and the VEGF application group was found decreased when compared with untreated groups (3rd and 7th days) (p <0.05). Chitosan and VEGF application were effectiveincreasing antioxidant capacity of serum on the 7th day. Serum NOx levels decreased inthe VEGF treated groups on 3rd and on 7th days (p<0.05). It can be considered that VEGFadministration has a more positive systemic effect to eliminate increased oxidative damagein the serum of normoglycemic rats.

• ÖZ

In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.