In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.