• ÖZ

Objective: Migraine is the most common primary headache among the paediatric population. The frequency of the condition causes a negative effect on children and parents, affecting the quality of life. Migraine and other primary headaches may result in sleep interruption, insomnia, hypersomnia and daytime sleeping. In this study, the quality of life and sleep disorders of children aged 8-18 years with migraine were assessed and compared with a healthy cohort. Materials and Methods: This study included 43 children or adolescents aged 8-18 years with acute migraine attacks, diagnosed according to the International Headache Society criteria. Parents completed ‘‘the children’s sleep habits questionnaire’’ and ‘‘pediatric quality of life inventory’’ tests. The control group included 48 children and adolescents without headache and a diagnosis of migraine. The two groups were compared to assess the negative effects of migraine on children. Results: The mean ages of the patient (15 boys and 28 girls) and control groups (25 boys and 23 girls) were 13.81±2.78 and 12.56±3.5 years, respectively. The physical health total score (p=0.000), emotional functioning score (p=0.019), school functioning score (p<0.000), psychosocial health total score (p<0.000) and the total scale score (p<0.000) were significantly lower in the patient group. No significant difference was noted in the social functioning score (p=0.383). Additionally, the groups did not differ significantly in terms of sleep behaviour (p>0.05). Conclusion: The results of this study were similar to those of previous studies, with the exception of decreased social functioning score of the pediatric quality of life inventory. These results substantiate the importance of administering appropriate treatment for pain control in children and adolescents. Specialists and parents should be aware of the potential social problems resulting from migraines.

• ÖZ

Objective: The aim of this study was to identify serum uric acid (UA) concentrations according to disease stage in patients with Alzheimer-type dementia (AD),and to collect data related to the hypothesis that oxidative stress is effective on the etiopathogenesis and progression of disease stage.Materials and Methods: The study was conducted with 180 patients who were categorized into disease stages in accordance with the Clinical Dementia RatingScale (CDR) and 150 healthy individuals of the same age group. In our retrospective study, patients who showed more than one cognitive deficit and diagnosedwith possible AD according to the diagnostic criteria of National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease andRelated Disorders Association were administered the CDR, Mini-Mental Test (MMSE), Geriatric Depression Rating Scale (GDRS), and individuals in the controlgroup were administered the MMSE and GDRS. Venous blood samples for biochemical studies were collected after 12-14 hours of fasting in the patient andcontrol groups.Results: In patients diagnosed as having AD, it was found that there was a statistically significant increase in age and duration of disease parallel with theprogression of disease stages, and a decrease in UA and albumin concentrations in both males and females (p<0.05).Conclusion: Our study supports the hypothesis that the decrease detected in serum UA concentrations in parallel with the progression of disease stages isdirectly related to the pathogenesis of AD.For the identification of chronic progressive diseases such as AD and to take precautions, the identification of variations in easily accessible and low-cost parameterssuch as serum albumin and UA concentrations in the early stages becomes important. In future years, when neuroprotective and neuro-restorative treatmentoptions are available, identification of serum UA values as a marker of disease progression and knowledge of the association between serum UA concentrations anddisease stage in our data will guide and support research into disease etiology.