Objective: The present study aimed to investigate theincidence of lower urinary tract symptoms, overactive bladder (OAB)syndrome, and erectile dysfunction (ED) in chronic obstructive pulmonarydisease (COPD) patients. Material and Methods: The studyincluded a total of 707 male patients with COPD. The Overactive BladderQuestionnaire, the International Prostate Symptom Score (IPSS),and the International Index of Erectile Function (IIEF) were administeredto each patient. Additionally, each patient was also queried as to whetherthey had any loss of libido. Pulmonary examination was performedbased on physical examination findings, spirometric measurements, andarterial blood gas analyses. Results: Mean age of the patients was52.5±10.6 years and a significant relationship was found between patientage and ED and lower urinary tract symptoms (p=0.01). Mean body massindex (BMI) was 33.2±5.6 kg/m2. A significant relationship was foundbetween BMI >35 kg/m2 and ED (p=0.042). Mean OAVB-V8 score was7.71±4.44. Mean IPSS score was 10.3±5.7 and mean IIEF score wasfound to be 11.6±6.44. A significant relationship was established betweensevere and most severe COPD and lower urinary tract symptoms includingurgency and urge incontinence (p=0.035 and p=0.021, respectively).A significant relationship was detected between COPD severity and ED(p=0.001). Moreover, the incidence of ED was higher in patients withoxygen saturation of ≤90 (p=0.044). Normal libido was reported by 91%of the patients. Conclusion: Our results indicated that the prevalence ofED is increased in patients with severe and most severe COPD and thatthe prevalence of lower urinary tract symptoms (especially urge incontinenceand urgency) is higher in COPD patients.
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OBJECTIVE: In recent years, the number of infertile couples who desire pregnancy with assisted reproduction techniques is increasing. Smoking and alcohol consumption are important factors affectingthe treatment of fertility and assisted reproductive techniques. To evaluate the effect of smoking and alcohol consumption on spermiogram resultsSTUDY DESIGN: This prospective case-control study was conducted at current urology and infertilitydepartment in a tertiary research hospital and a total of 6171 cases included in the study. Data collectedand evaluated were age and sperm parameters (liquefaction, semen volume, sperm concentration, totalnumber, total motility, progressive motility, slow motility, non-progressive motility, morphology).RESULTS: Of 6171 patients; a total of 3247 men was smoker (n:3247, %52.6) and 3511 was alcoholusers (n:3511, %56.9). Mean age of the patients in the study group was 32.8±6.5 years. There was a statistically significant difference between the smoker and nonsmoker in terms of sperm concentration andslow motility (p <0.05). There was a statistically significant difference between alcohol consumption andno alcohol consumption in terms of; semen volume, sperm concentration, normal morphology (p <0.05).CONCLUSION: According to this study, smoking has a negative effect on sperm concentration and slowmotility. Alcohol consumption has a negative impact on semen volume, sperm concentration, normalmorphology. Smoking and alcohol consumption separately and combined were found to have a deleterious effect on sperm parameters. It is suggested that both habits may contribute to infertility problems.
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OBJECTIVE: In this study, the effects of sperm parameters on the success of intrauterine insemination were investigated. STUDY DESIGN: The data from 309 infertile couples who were admitted between 2012-2018 without a female factor were analyzed retrospectively and included in the study. After the administration of go-nadotropin and hCG (5000-10000 IU), single insemination was performed in 36-40 hours in all cycles. All couples underwent routine infertility screening. The relationship between sperm parameters (motility, morphology, sperm count), patient age, duration of infertility with intrauterine insemination success was evaluated. RESULTS: There was no statistically significant difference between the two groups in terms of mean age and age related-parity. There was no statistically significant difference between male ages, lique-faction, and sperm volumes between the two groups (p=0.898, p=0.448, p=0.651). Before washing; There was a statistically significant difference between the sperm concentration, percentage of total motile sperm, percentage of progressive motility sperm, percentage of normal sperm morphology, and total sperm count between the two groups (p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.0001). After sperm washing; the results were similar to those obtained before washing. While statistically significant difference was observed between sperm volume and sperm concentrations (p=0.023, p=0.018), no sig-nificant difference was observed between the two groups in total sperm count (p=0.612). CONCLUSION: As a result, during the application of intrauterine insemination to infertile couples, total motile sperm count, progressive motility sperm count ratio and high sperm ratio with normal morphology used in order to increase pregnancy success can be considered as criteria that increase the chances of success.
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Purpose: In our study the diagnostic role of HMGB1 levels measured in serum were investigated in prostatitis and prostate carcinoma diagnosis and in the differential diagnosis of these two diseases. Material Method: Patients followed up for histopathologically verified diagnosis of prostate carcinoma and prostatitis in 20142017 at the Urology Clinic were included. HMGB1 measurement in serum was performed with the ELISA method. Results: A total of 78 subjects were included in the study, consisting of 30 (38.5%) prostatitis patients, 25 (32%) prostate carcinoma patients and 23 (29.5%) healthy subjects. HMGB1 was detected as 11.9±2.6 (Range 6.7-18.4) ng/ml in the prostatitis group, 15.1±4.5 (Range 8.4-24.8) ng/ml in the prostate carcinoma patients and as 9.2±3.1 (Range 4.7-18.7) ng/ml in the control group. The difference between the groups were investigated using the Friedman test as HMGB1 did not show normal distribution. Significant difference was detected between the three groups (p<0.001). When the groups were compared in pair, significant difference was detected between the prostatitis group and the control group (p=0.001). Significant difference was again detected between the prostate carcinoma group and the control group (p<0.001). Significant difference was detected between the prostatitis group and the prostate carcinoma group (p=0.006). Measurement of serum total prostate specific antigen (tPSA) levels were conducted automatically with the electro chemiluminescent method. A moderate level of (r=0.276) but a highly significant (p=0.009) positive correlation was found between PSA and HMGB1. Conclusion: In our study we showed that high PSA and high HMGB1 were highly correlated. HMGB1 measured in serum could be a useful marker in the differentiation of prostatitis and prostate carcinoma, in the early diagnosis of suspected prostate carcinoma and that HMGB1 value was significantly high in prostate carcinoma patients.
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Objective: Urinary incontinence (UI) is involuntary urine flow that causes social and hygienic problems. The association between risks factors and UI in women was assessed. We compared the risk factors based on UI subtypes.Methods: The study included 470 women with different UI types (320 urge UI [UUI], 80 stress UI [SUI], and 70 mixed UI [MUI]).Age, educational level, urban/rural residence, parity, delivery type, diabetes mellitus (DM), and hypertension status, anyneurological abnormality, menopausal status, surgical history, and body mass index (BMI) were obtained.Results: Of all women, 320, 80, and 70 had UUI, SUI, and MUI, respectively. The groups did not differ significantly in terms ofage, hypertension status, neurological abnormality rate, smoking status, or surgical history (all p>0.05). Parity, episiotomy,DM status, delivery type, menopause status, hysterectomy history, and BMI differed significantly among the groups (allp<0.05).Conclusion: Our study found that parity, episiotomy, DM status, delivery type, menopause status, hysterectomy history, andBMI may be independent risk factors for different UI types.
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Objective: We aimed to compare the ef-ficiency of cold knife urethrotomy and laser urethrotomy in endoscopic surgery of urethral strictures.Material and Methods: A total of 171 patients were evaluated retrospectively. A 118 patients with complete data were divided into two groups (group 1; n = 53 cold knife ure-throtomy, group 2; n = 65 laser urethrotomy) in the study. Length of the stricture, operation time, preoperative and postoperative 3rd, 6th and 12th-month Qmax values, recurrence and the presence of complications (such as bleed-ing, extravasation, fever etc.) were compared in terms of the two groups.Results: The operation time was found to be shorter in patients who underwent cold knife urethrotomy (14.01 ± 3.86 min vs 25.03±4.43 min, p=0.001). The Q max values at the postoperative 3rd, 6th and 12th months were ob-served to be higher in patients who underwent laser urethrotomy (p=0.03, p=0.001, p=0.001). At the end of a one-year follow-up, recurrence was determined in 28 (52.83%) patients in group 1 and 12 (18.46%) patients had a recur-rence in group 2 (p=0.01). No statistically sig-nificant difference was observed between the two groups in terms of postoperative complica-tions. (p=0.209).Conclusion: In this study, it was deter-mined that laser urethrotomy technique was a more successful surgical method than cold knife urethrotomy in the endoscopic surgery of urethral strictures as it has higher Qmax values and lower recurrence rate. The results should be supported by prospective, randomized studies.
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Objective: We aimed to test ocular and systemic safety of mirabegron medication in the treatment of overactivebladder in elderly patients.Method: A total of 74 patients (40 male, 34 female) with symptoms of overactive bladder admitted to the urologyclinic were included in the study. Patients over 60 years old were included. Patients were followed-up for 3 months.Symptom scores (according to OAB-V8 form), intraocular pressure (IOP) readings of right and left eyes, systolic anddiastolic blood pressures of the patients were recorded before and after the treatment. At the end of 3 months, allvalues were re-evaluated and compared with pre-treatment data.Results: Mean age was 69.48±7.8 years. The symptom score was found to be 18.67 ± 9.87 before the treatment and9.83 ± 2.71 after 3 months of the treatment (p=0.0001). Right eye mean IOP value was 16.06 ± 2.62 mmHg beforetreatment and 15.85 ± 2.31 mmHg after treatment (p=0.341). Left eye mean IOP value was 15.96±2.35 mm mmHgbefore treatment and 15.94±2.21 mm after treatment (p=0.855). Systolic blood pressure measurements were128.91±11.76 mmHg before treatment and 128.43±11.95 mmHg after the treatment (p=0.110). Diastolic bloodpressure measurements were 81.94±9.83 mmHg before the treatment and 81.31±10.14 mmHg after the treatment(p=0.071).Conclusion: Treatment of overactive bladder with mirabegron 50mg/day is well tolerated and safe in elderly patients.
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Prostate cancer is one of the frequently seen types of cancers in men. The most frequent histological typeof prostate cancer is the acinar adenocarcinoma. Mucin-producing urothelial-type adenocarcinoma of theprostate is a very rare subtype. The mucin-producing urothelial-type adenocarcinoma of the prostate hasmicroscopic similarities with colon and bladder adenocarcinoma. It has a more aggressive clinical courseand does not respond to androgen deprivation therapy. A 77-year -old male patient diagnosed with mucinousprostate cancer was presented in the current case report
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