Introduction: The primary aim of our study was to investigatethe relationship between hypertensive diseases of pregnancy(HDP) and blood groups. Our secondary aim is to determinethe risk factors that play a role in the development of HDP.Methods: Pregnant women aged 15-49 years were includedin this cross-sectional, observational, and prospective study.Pregnant women were divided into two groups. Group 1(n=266) included patients admitted to the intensive care unitdue to HDP. Group 2 (n=402) included normotensive patientswithout any complications during pregnancy. The groups werecompared in terms of age, blood groups, Rh factor, gravida,parity, gestational week, and primiparity-multiparity.Results: There was no statistically significant differencebetween the groups in terms of ABO blood group and Rh factor.The mean age, gravida, and parity were significantly higher inGroup 1 than in Group 2 (p=0.028; 0.001; 0.004, respectively),while mean gestational age was lower than Group 2 (p<0.001).We also found that high gravida, low gestational age, presenceof comorbidity, and primiparity were risk factors for HDP.Conclusion: We did not find any relationship between HDPand blood groups. We found that high gravida, low gestationalage, presence of comorbidity, and primiparity are risk factorsfor HDP.