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Introduction: Although atherosclerotic cardiovascular diseases and cardiovascular risks are known to increase in patients with end-stage renal disease, it is not clear whether these risks increase in the geriatric patient population as well. This study aims to evaluate these risks in geriatric patients with end-stage renal disease by evaluating epicardial fat and carotid and femoral intima-media thicknesses, known as markers, for subclinical atherosclerosis and cardiovascular risks. Materials and Methods: This cross-sectional study included 52 patients who started to receive chronic hemodialysis treatment after the age of 65 years (mean age 73.92±5.63) years with end-stage renal failure and 51 healthy volunteers (mean age: 74.49±4.63 years). Epicardial fat and carotid and femoral intima-media thicknesses were measured and compared between these groups. Results: Carotid intima-media and epicardial fat thicknesses were significantly higher in the patient group than in the control group (0.91±0.08 vs. 0.71±0.1 mm, p<0.001 and 0.84±0.17 vs. 0.75±0.17 cm, p=0.01, respectively). However, no significant difference was observed in femoral intima-media thickness between the two groups (0.58±0.07 vs. 0.56±0.97 mm, p=0.266). Correlation analysis revealed a significant positive correlation between the duration of dialysis and epicardial fat and carotid intima-media thicknesses (r=0.611, p<0.001 and r=0.337, p=0.015, respectively). Furthermore, regression analysis revealed a significant relationship between the duration of dialysis and carotid intima-media thickness (β=0.657, p=0.001). Conclusion: Epicardial fat and carotid intima-media thicknesses increase in geriatric patients with end-stage renal disease but with no significant changes in femoral intima-media thickness, indirectly suggesting that subclinical atherosclerosis and cardiovascular risks are increased in these patients.

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Amaç: Hipertrofik kardiyomiyopati hastalarında subklinik koroner ve karotis aterosklerozu riskinin artıp artmadığı bilinmemektedir ayrıca epikardiyal yağ dokusu ve karotis intima‐media kalınlıklarının genel popülasyonda kardiyovasküler riskleri gösterdiği net olarak gösterilmiş olmasına rağmen, hipertrofik kardiyomiyopati hastalarında ani kardiyak ölüm riskini gösterip göstermediği net değildir. Bu çalışmanın amacı bu riskleri değerlendirmektir. Gereç ve Yöntem: Çalışma kesitsel olarak dizayn edildi. Hipertrofik kardiyomiyopatili 58 hasta ve hasta grubu ile benzer demografik özelliklere sahip 57 sağlıklı gönüllü çalışmaya dahil edildi. Hasta grubundaki bireylerin 5 yıllık ani kardiyak ölüm riskleri hesaplanarak kaydedildi. Her iki grupta epikardiyal yağ dokusu ve karotis intima‐media kalınlıkları ölçülerek aralarında istatistiksel anlamlı fark olup olmadığı karşılaştırıldı. Ek olarak ani kardiyak ölüm riski ile epikardiyal yağ dokusu ve karotis intima‐media kalınlıklarının korele olup olmadığı da değerlendirildi. Bulgular: Epikardiyal yağ dokusu kalınlığı hasta grubunda istatistiksel anlamlı olarak yüksek bulundu (6,06±0,7 mm vs. 5,31±0,86 mm, p<0,001) ancak bu artış ani kardiyak ölüm riski ile korele değildi (r=0,151, p=0,257). Diğer taraftan karotis intima‐media kalınlığı bakımından iki grup arasında anlamlı fark bulunmadı (0,54±0,05 mm vs. 0,53±0,52 mm; p=0,148) ve karotis intima‐media kalınlığı ani kardiyak ölüm riski ile korele değildi (r=0,177, p=0,184). Sonuç: Hipertrofik kardiyomiyopatili hastalarda kontrol grubuna kıyasla epikardiyal yağ dokusu kalınlığı artmış, karotis intima‐media kalınlığı ise değişmemiştir. Gerek epikardiyal yağ dokusu kalınlığı gerekse karotis intima‐media kalınlığı hipertrofik kardiyomiyopati hastalarında hesaplanan 5 yıllık ani kardiyak ölüm riski ile korele değildir.

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Aim: Even though it is well known that major adverse cardiac event rates elevate in cardiac syndrome X (CSX) patients, it is not clearly known whether the risk of atrial fibrillation (AF) and ventricular arrhythmia (VA) is elevated or not. The purpose of this study was to evaluate AF and VA risks. Therefore, P wave dispersion (PWD), an indicator of development of AF; and corrected QT interval dispersion (CQTD), Tp-e interval, Tp-e interval/corrected QT ratio, which demonstrate the risk of development of VA, were assessed in CSX patients. Methods: The study was realized as a retrospective trial. A total of 298 subjects (155 CSX patients, 143 controls) were examined. PWD, CQTD, Tp-e interval, Tp-e interval/corrected QT ratio were calculated and compared between both groups. Results: PWD, CQTD, Tp-e interval, Tp-e interval/corrected QT ratio values were elevated in CSX patients compared to the healthy subjects (p=0.003, p<0.001, p<0.001 and p<0.001 respectively). Conclusion: Based on these outcomes it may be thought that CSX patients have increased atrial and ventricular repolarization abnormalities compared to normal population. Furthermore, our results may indirectly indicate that patients with CSX have increased risk of AF and VA.

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Objective: Breast cancer is the most common cancer in women. Trastuzumab is an effective breast cancer agent. The most significant side effect of trastuzumab is left ventricular systolic dysfunction. Selvester score calculated from 12-lead electrocardiography (ECG) has a proven accuracy in predicting left ventricular infarct area and scar volume. We aimed to determine its role in detection of left ventricular systolic dysfunction among trastuzumab-treated breast cancer patients. Methods: A total of 60 trastuzumab-treated patients were retrospectively included. The patients were grouped into two groups with trastuzumab-induced left ventricular systolic dysfunction (left ventricular ejection fraction (LVEF) <55%) (Group 1) and without (Group 2). The left ventricular systolic dysfunction group was divided into two subgroups: LVEF <50% and (Group 1a) and LVEF 50–54% (Group 1b). The Selvester score was compared between Group 1 and Group 2, and between Group 1a, Group 1b, and Group 2. The predictive role of Selvester score in trastuzumab-induced left ventricular systolic dysfunction was determined with univariate and multivariate analysis. Results: The mean age of the patients was 56.7±13.7 years. Twenty (21.1%) patients had trastuzumab-induced left ventricular systolic dysfunction. The Selvester score was similar between Group 1 and Group 2. Group 1a had a significantly greater Selvester score compared to Group 1b and Group 2 (p<0.05); however, Group 1b and Group 2 had similar Selvester scores (p>0.05). The Selvester score was significantly correlated with left ventricular systolic dysfunction in univariate analysis (r=0.189, p<0.05) but not in multivariate analysis. Conclusion: Selvester score may be useful especially for detecting severe trastuzumab-induced left ventricular systolic dysfunction.

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Aim: Elevated red blood cell distribution width (RDW) and mean platelet volume (MPV) levels which are closely associated with chronic inflammation and platelet aggregation are suggested as independent predictors of obesity and cardiovascular diseases. However influence of significant weight loss following bariatric surgery on these parameters is unknown. Therefore we aimed to find out the effect of significant weight loss following laparosco-pic sleeve gastrectomy (LSG) on RDW and MPV levels.Methods: The medical data of 98 morbid obese subjects (25 male, 73 female) who were operated between February 2015 and June 2017 according to indications of bariatric surgery in current guide-lines including body mass index (BMI) >40 kg/m2 or BMI= 35-40 kg/m2 with additional comorbidities were recorded. The difference bet-ween baseline and values at one year was expressed as a delta (Δ).Results: The mean age of our study population was 41.89±11.99 years and mean weight loss in one year after LSG was 45.41±13.13 kg (36.5%). BMI decreased from 46.60±7.11 kg/m2 to 29.58±4.63 kg/m2. Compared to the baseline, significant decreases in RDW (14.61±1.69 % vs. 13.71±2.10 %; p<0.01) and MPV (8.63±1.45 vs. 7.92±1.24 fL, p<0.001) levels were found in the postoperative one-year values. In addition; ΔVKI was positively correlated with ΔRDW (r=0.343, p<0.01) and ΔMPV (r=0.322, p<0.01).Conclusion: We found that morbid obese subjects have signifi-cantly decreased RDW and MPV levels which are correlated to their weight loss in one-year follow-up after LSG. If we think that several factors may affect these parameters, conduction of further pros-pective large-scale studies are needed.