Aim: Stroke is one of the leading and most challenging problems in distinguishing between central and peripheral causes of acute vestibular syndrome. This study aims to evaluate the potential utility of neutrophil to lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and gamma-glutamyl transferase (GGT) levels in the differential diagnosis of acute vestibular syndrome. Materials and Methods: This retrospective study included 152 patients diagnosed with vestibular neuritis (VN) and posterior circulation ischemic stroke (PCIS) within the scope of the isolated acute vestibular syndrome (AVS: vertigo, nystagmus, nausea-vomiting, postural instability, and intolerance of head movements). Of all these patients, we listed the ones having normal MRI findings and diagnosed with VN in the department of otorhinolaryngology. The diagnosis of stroke was made through neuroimaging methods (CT and MRI). NLR and GGT levels were compared among the patients diagnosed with VN and PCIS. Results: GGT, NLR, PLR levels were significantly higher in the patients with the PCIS group (p<0.05). The AUC (area under the curve) and optimal cutoff values for NLR, PLR, and GGT were analyzed by ROC analysis. According to these results, the diagnostic value of NLR was higher in predicting stroke (AUC: 0.741; 95%CI: 0.652-0.829, p<0.001)Conclusion: As a result, NLR, GGT, and PLR can be useful biomarkers for deciding in favor of stroke in the differential diagnosis of VN.
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Aim: Among cardiovascular diseases, pulmonary embolism (PE) is a serious emergency with high mortality. Right ventricular dysfunction due to an excessive increase in pulmonary artery pressure is considered a major cause of death in vigorous PE. We aimed to assess the predictive value of computed tomographic pulmonary angiography (CTPA)-based morphometric measurements of right heart function in the diagnosis of PE.Materials and Methods: This is a retrospective, case-controlled study. A total of 198 cases were included in the study during the study phase. CTPA results of 102 patients with PE were recorded, and the patients were grouped according to clot localisation. The diameters of the inferior vena cava (IVCA), aorta, pulmonary artery and right and left ventricles were assessed. Results: IVCA area/aortic area significantly predicted embolism in the main pulmonary artery [area under the curve (AUC)=0.957, p<0.001]. The optimal cut-off value was 1.22 with 88% sensitivity and 90% specificity. IVCA diameter/aortic diameter significantly predicted embolism in the main pulmonary artery (AUC=0.955, p<0.001). The optimal cut-off value was 1.1 with 89% sensitivity and 88% specificity.Conclusion: Our study illustrated a remarkable association between the existence and dispersion of PE and morphometric changes in IVCA and aortic ratio parameters measured using CTPA.
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Aim: We investigated the development of epistaxis and the effect of red blood cell distribution (RDW) and mean platelet volume(MPV) levels in hypertensive patients compared to non-hypertensive patients. Epistaxis is an urgent rhinologic condition that maymanifest itself as recurrent hemorrhages in small quantities or life-threatening hemorrhages. It is known that epistaxis does notdevelop in every hypertensive patient.Material and Methods: In this retrospective study, the participants were divided into four groups as follows: Group 1 hypertensiveepistaxis, Group 2 isolated epistaxis, Group 3 isolated hypertension, Group 4 control. RDW and MPV values were obtained fromcomplete blood count (CBC) samples.Results: There was a statistically significant difference in RDW and MPV blood parameters between all groups (p=0.02). When RDWand MPV blood parameters of Group 1 with hypertensive epistaxis and Group 3 with isolated hypertension were evaluated, there wasa statistically significant difference between these two groups in both parameters (p = 0.000, p = 0.011).Conclusion: In our study, we showed that the decrease in RDW and MPV values among the hematological parameters increases theassociation of epistaxis with hypertension in hypertensive patients compared to non-hypertensive patients.
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AbstractAim: There is a balance between reactive oxygen species (ROS) and antioxidant systems preventing them in the organism. In cases where this balance is impaired, molecular and cellular functions are negatively affected. Thiol-disulfide homeostasis (TDH) is also affected by this imbalance. It has been reported that the balance between oxidative and anti-oxidative systems is disrupted in individuals with psychiatric diseases such as anxiety and depression. Accordingly, it was aimed to determine the level of TDH in the serum of students who took the oral internship exam.Material and Methods: Volunteer fifth grade students of Medical Faculty, 19 male and 21 female, was included in the study. Of the students included in the study, Beck depression and Beck anxiety, albumin, ischemia-modified albumin (IMA), total thiol (SH + SS), native thiol (SH) and SS levels were measured and SS / SH + SS %, SH / SH + SS % and SS / SH % were calculated before and after the oral internship exam. These data were compared with the association between anxiety and depression level changes before and after the oral internship exam.Results: It was observed that the anxiety levels of the participants before the oral exam decreased in the period after the oral exam (p<0.001). It was detected that the level of depression of the participants before the oral exam decreased after the oral exam (p<0.001). Changes in IMA and TDH parameters before and after the oral internship exams were examined, but no significant relationship was found (p>0,05).Conclusion: Oral internship exam of Medical Faculty is a factor increasing anxiety and depression levels of the students. However, no association was found between oral internship exam and TDH parameters.
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Backround: The aim of this study is to investiate whether patints with acute myocardial infarctin exhibited diurnal variatin and the relatinship between the affcted coronary artery and this diurnal variatin.Material and Methods: The patints admittd to the emergency department of Yozgat Bozok Universitywith symptoms of acute coranary syndrome between January and December 2017 were retrospectielyanalyzed. In 24 hour period diurnal changes were analyzed in 6 groups (00:01-04:00, 04:01-08:00, 08:01-12:00, 12:01-16:00, 16:01-20:00, 20:01-00:00), seasonal changes were analyzed in 4 groups (Spring,Summer, Autumn, Winter), and weekly changes were analyzed in 2 groups (Weekday, Weekend).Results: When diurnal effcts coronary arteries were examined, no statitially signifiant results werefound. When the changes of diurnal effct were observed at weekdays and weekends, it was found thatall three coronary artery lesions were statitially increased at weekdays compared to the lesions seen atweekends (p<0,05).Conclusion: Although daily diurnal variability was not detected as a result of our study, it was clearlydetermined that the increase in coronary artery disease was affcted by social reasons such as stress andintensive work pace during the weekdays
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