Objectives: Respiratory problems increase the number of epileptic seizures in individuals with epileptic seizures. This study aimed to determine the relationship between the number of seizures, sleep quality, and respiratory problems by evaluating the changes in respiratory parameters of epileptic patients. Methods: Thirty individuals aged 18–40 years with generalized epilepsy were included in the study. Demographic data, number of seizures per week, pulse and blood pressure measurements, age of seizures, and body mass index were recorded. Dyspnea with mMRC; pulmonary function test; level of physical activity (PA) with International physical activity assessment survey (IPAQ); mouth pressure measuring device with respiratory muscle strength; and sleep quality with Pittsburgh Sleep Quality Index (PSQI) were evaluated. Results: Thirty patients with epileptic seizures (mean age: 26.56±6.64 years) were included in the study. The mean; % maximal inspiratory pressure (MIP) 67.44, %Maximal expiratory pressure (MEP) 35.14, MIP 70.47, and MEP 62.24 cmH2 O were found. The forced expiratory volumes/ forced vital capacity (FEV1 /FVC) (41.01%) and FEV1 (62.50%; 2.56 L) was found lower than the standards. The positive correlation between the MEP, MIP, FEV1 (L), and severe PA was found. FVC with sitting, FEV1 (L) with moderate PA, and FEV1 /FVC (%) with PSQI, sitting with educational status were positively correlated (p<0.05). There was a negative correlation between the %MIP and a systolic blood pressure; MIP, MEP (% and cmH2O) with diastolic blood pressure (p<0.05), and a positive correlation between the %MEP and SpO2 (p<0.05). Conclusion: As a result, respiratory function, PA, and the sleep quality of individuals with epilepsy were affected. Respiratory muscle training, PA programs, and behavioral changes should be added to the medical treatment programs of these individuals.
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Objective: The aim of the current study was to determine the relationship between serum S100B levels, NSE levels and hearing function in patients with OSAS. Material and Methods: Thirty-five subjects and 30 controls were included in the study. The study group included 35 patients with moderate and severe apnoea (AHI > 15) who were diagnosed by polysomnography (PSG). Control subjects were selected with ESS (Epworth Sleepiness Scale). Serum S100B and NSE levels in the study and control groups were analyzed by ELISA (enzyme-linked immunosorbent assay) and high-frequency audiometry was done for all subjects. Results: Mean S100B levels and NSE levels of the OSAS group were significantly higher than that of the controls (p = 0.039; p = 0.002, respectively). The hearing thresholds between 125-1,000 Hz and between 4,000-12,000 Hz in the study group were found to be significantly higher than the control group. Conclusion: We suggest that hearing function should be evaluated in OSAS patients and a professional consultation should be sought for OSAS treatment. In addition, serum S100B and NSE measurements may be valued as biochemical indicators in determining hearing loss risk caused by OSAS.
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