Background/aim: Water immersion and epidural analgesia are the most preferred pain relief methods during the labor process. Adverse
effects related to these methods, impact on the labor, and perception of pain is well studied in the literature. We aimed to investigate the
cord blood level of copeptin, total serum oxidant (TOS), antioxidant (TAS), interleukin (IL)-1, IL-6, and oxytocin after the labor with
water immersion, epidural analgesia, and vaginal birth without pain relief.
Materials and methods: The study was conducted with 102 healthy pregnant women admitted to the obstetric delivery unit for
noncomplicated term birth. Copeptin, oxytocin, TAS, TOS, IL-1, and IL-6 levels of cord blood and obstetric and neonatal results after
vaginal birth were compared.
Results: The study included a total of 102 patients (group 1 = 30, group 2 = 30, and group 3 = 42). We found no significant difference
between the three groups in terms of BMI, age, gravidity, parity, birth week, birth weight, interventional birth, perineal trauma,
breastfeeding, duration of labor, oxytocin, IL-1 and IL-6 levels (p > 0.05). Neonatal intensive care unit (NICU) need, TAS, TOS, and
copeptin levels were higher. Apgar scores were lower in the epidural group (p = 0.011, p = 0.036, p = 0.027, p < 0.001, and p < 0.001
respectively).
Conclusion: Epidural analgesia has deteriorated oxidative stress status and lower neonatal Apgar scores with higher NICU administration
compared with water birth and vaginal birth without pain relief.
Key words: Epidural analgesia, infection, neuroendocrine, oxidative stress, waterbirth
